New ion exchange chromatographic column for protei

2022-08-07
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Experimental force limitation

wattage has launched a new ion exchange chromatographic column for qualitative analysis of proteins

the waters UPLC technology is used to improve the charge monitoring of biological therapeutic proteins

wattage company (wat:nyse) has recently launched a protein Pak hi res ion exchange (IEX) chromatographic column for the analysis of biological molecules on the wattage acquity UPLC system, including monoclonal antibodies, recombinant proteins, dna/rna and vaccines. Biotherapeutic drug manufacturers use this chromatographic column to analyze various band states of complete biomolecules, which can obtain higher resolution, faster analysis speed and better reproducibility., Therefore, the monitoring capability is improved, which is conducive to the high-quality and efficient production of manufacturers

the development of the protein Pak hi res IEX series chromatographic column of watsch is to qualitatively analyze the recombinant proteins and monoclonal antibodies found in many new biopharmaceutical therapies by using UPLC technology. Compared with the traditional porous IEX particle technology, these nonporous and high bonding density particle technologies have higher peak capacity and higher resolution in macromolecule separation. In addition, the new particle technology and surface chemical properties also improve the sample carrying capacity and resolution of the chromatographic column, and minimize the pollution of the chromatographic column

the bonding phases of ion exchange bonded on the surface of polymer particles include strong anion exchange (quaternary ammonium salt, q) and weak strong cation exchange substances (carboxymethyl (CM) and reduce the number of process equipment by 75% and sulfonyl (s)). They can withstand high salt concentration and high pressure within the pH range. Ion exchange chromatography has proved to be an important technique for assessing the charged state of biomolecules. The reproducibility of biomolecular production is a difficult problem. The change of protein charge is a good sign of deamidation or glycosylation, which will affect the stability and efficacy of the product, so it needs to be closely monitored. For more details, please visit the station

the ability of UPLC technology was extended to the on-site acceptance of Henan Kechuang aluminum based new materials Co., Ltd., which was independently established by Henan high efficiency aluminum based new materials innovation center. Biomolecule

in 2004, wuteshi company launched the acquity UPLC system, which completely changed the LC separation technology. Compared with the traditional HPLC Technology, UPLC technology greatly improved the sample flux. The perfect combination of the latest protein Pak hi res IEX chromatographic column of water world company and acquity UPLC system can obtain the highest sensitivity while maintaining the resolution of key components. In addition, each chromatographic column adopts watsch acquity UPLC ecord technology, which is helpful to monitor the service parameters of a single chromatographic column throughout the life cycle of the chromatographic column – information is always with the chromatographic column

in a word, these combined technologies have greatly enhanced the qualitative analysis ability of single antibody, recombinant protein, DNA or RNA and vaccine components in the process of aluminum alloy cupping and cupping test

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